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KMID : 0378019850280020065
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New Medical Journal
1985 Volume.28 No. 2 p.65 ~ p.76
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Clinical Study of Cefaperazone Sodium (Cefobid^(®)) in the Treatment of Bacterial Infection in the Practice of Pediatrics
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Abstract
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An analysis presented 100 cases of severe bacterial infection in Korean Infants and Children, treated at the Department of Pediatrics, Yonsei University Severance Hospital from Feb. 1983 to April 1984.
Ninety-one cases were received previous antibiotics before Cefobid treatment and 9 cases all post-operation of Congenital heart disease state were received Cefobid treatment without previous antibiotics.
The age distribution was from l day to 15 years old.
A dose of 50-200mg/kg divided four times daily was administered intravenously. Among the 100 cases, Sepsis was 29 cases, Pneumonia was 29 cases, Meningitis was 8 cases, Urinary tract infection was 7 cases, Other diseases were 18 cases and Post-op of CHD was 9 cases.
The effect of treatment was divided into 3 groups (e.g. Excellent, Good, Poor). The ,overall- satisfactory responses was 86%, and 79% in Sepsis, 86% in Pneumonia, 88% in Meningitis, 100% in UTI, 83% in Other diseases and 100% in Post-op of CHD.
The satisfactory response rates for organisms were as follows: Staphylococcus species .22/23, Streptococcus species 3/4, Enterobacter 3/3, Klebsiella 6/8, E. coli 4/5, Pseudomonas species 2/4, Acinetobactor species 2/3, Serratia marcescens 1/1 and Neisseria meningitides :2/2.
We found no particular side effects, except for 7 cases of Rash/Skin reaction, 5 cases of Fever, 3 cases of Diarrhea/loose stool, 1 case of Urticaria, 1 case of Vomiting and 1 case of Headache.
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